东华大学 化学化工与生物工程学院 权静（副教授）导师介绍

权静，1977年6月，2007年6月毕业于浙江大学化学系，获理学博士学位。同年7月进入东华大学化学化工与生物工程学院生物科学与技术研究所，2009年10月晋升副研究员。到目前为止发表各类学术论文50多篇，其中已发表待发表SCI收录科技论文28篇（累积影响因子IF>60），作为第一作者和通讯作者已发表论文15篇（影响因子IF>3的论文4篇，IF>4的论文1篇），文章累计被引用次数超过50次；已发表EI/ISTP收录论文12篇；中文源刊论文11篇；已申请中国发明16项专利，授权4项。
近年来，主持并参与课题的国家级、上海市及其他科研项目总计近10项。与课题组长联合指导研究生10多名，其中两名博士生，五名硕士生已顺利毕业，三名毕业硕士连续两年获得“校优秀研究生”及“研究生一等奖学金”，一名毕业博士生连续两年获得“学术科研特等奖”及“校优秀研究生”称号，目前独立指导硕士生3人，本科生1人。

研究方向：

1、酶促合成药物衍生物的设计与研究;

2、新型高分子药物的设计、制备及性能研究;

3、仿生纳米材料可控制备及应用研究.

近年代表作：

1、Wu CY, Xie JG, Branford-White C, Quan J*, Zhu LM*, In Vitro Controlled Release of Polymeric Drug-Saccharide Conjugates with Ketoprofen, Ibuprofen and Naproxen Pendants. J. Appl. Polym. Sci., 2011, DOI: 10.1002/app.33735

2、Xie JG, Wu CY, Branford-White C, Quan J*, Zhu LM*, Ionic Liquids Promoted the S-Methylation of Thiols with Dimethyl Carbonate. Phosphorus Sulfur Silicon Relat. Elem. 2011, 186(1), 31-37.

3、Zheng Y, Branford-White C, Wu XM, Wu CY, Xie JG, Quan J*, Zhu LM*, Enzymatic synthesis of novel feruloylated lipids and their evaluation as antioxidants. J. Am. Oil Chem. Soc.,2010, 87 (3), 305-311.

4、Zheng Y, Wu XM, Branford-White C, Quan J*, Zhu LM*, Dual Response Surface-Optimized Process for Feruloylated Diacylglycerols by Selective Lipase-catalyzed Transesterification in Solvent Free System. Bioresour. Technol. 2009, 100 (12), 2896-2901.

5、Zheng Y, Wu XM, Branford-White C, Ning X, Quan J*, Zhu LM*, Lipase-catalyzed synthesis of novel feruloylated structured lipids in selected organic medium. J. Mol. Catal. B: Enzym. 2009, 58 (1-4), 65-71.)

6、Zheng Y, Jiang B, Quan J*, Zhu LM*, Enzymatic synthesis of 6-chloropurine riboside by whole cell of lactobacillus helveticus. J. Biotechnol. 2008, 136, S380-381.

7、Quan J, Chai YQ, Branford-White C, Zhu LM*, The purification and characterization of deoxycytidine kinase from calf thymus, World J. Microbiol. Biotechnol, 2009, 25 (3), 475-480.

8、Quan J, Lin XF, Zhu LM*, Progress in Enzymatic Synthesis of Drug Derivatives, Chin. J. Org. Chem., 2009, 29 (2), 143-151.

9、Quan J, Wu Q, Zhu LM, Lin XF*, Chemo-enzymatic synthesis and sustained release of optically active polymeric prodrugs of chlorphenesin, Polymer, 2008, 49 (16), 3444-3449.

10、Quan J, Zheng Y, Jiang B, Zhu LM*, Lin XF*, Improving solubility of lipophilic drug: Enzymatic synthesis of drug-saccharide derivatives in nonaqueous media. J. Biotechnol. 2008, 136, S514-514.

11、Quan J, Wu Q, Lin XF*, Synthesis of polymeric prodrugs of chlorphenesin with saccharide branches by chemo-enzymatic regioselective strategy. Polymer, 2007, 48 (9), 2595-2604.

12、Quan J, Wu Q, Lin XF*, The synthesis of amphipathic prodrugs of 1, 2-diol drugs with saccharide conjugates by high regioselective enzymatic protocol. Bioorg. Med. Chem. 2007, 15 (4), 1741-1748.

13、Quan J, Wang N, Wu Q, Cai XQ, Lin XF*, Controllable selective enzymatic synthesis of N-acyl and O-acylpropranolol vinyl esters and preparation of polymeric prodrug of propranolol. J. Mol. Catal. B: Enzym. 2007, 44 (1), 1-7.

14、Quan J, Xu JM, Liu BK, Zheng CZ, Lin XF*, Synthesis and characterization of drug-saccharide conjugates by enzymatic strategy in organic media. Enzyme Microb. Technol. 2007, 41 (6-7), 756-763.

15、Quan J, Chen ZC , Wu Q , Wang N, Lin XF* , Chiral separation of propranolol vinyl ester prodrug by high performance liquid chromatography. Chin. J. Anal. Chem. 2006, 34 (9), S78-82.

16、Wu CY, Quan J, Xie JG, Branford-White C, Zhu LM*, Yu Y, Wang YJ, Preparation and controlled release of degradable polymeric ketoprofen-saccharide conjugates. Polym. Bull., 2011, DOI: 10.1007/s00289-010-0409-4.

17、Xie JG, Quan J, Li SB, Zheng Y, Zhu LM*, SH-Methylation of SH-Containing Heterocycles with Dimethyl Carbonate via Phase-transfer Catalytic Reaction. Synth. Commun. 2011, 41(6), 871 – 878.

18、Yu Y, Zheng Y, Quan J, Wu CY, Wang YJ, Branford-White C, Zhu LM*, Enzymatic synthesis of feruloylated lipids: Comparison of efficiency of vinyl ferulate and ethyl ferulate as substrates. J. Am. Oil Chem. Soc. 2010, 87 (12), 1443-1449

19、Zheng Y, Quan J, Zhu LM*, Jiang B, He ZY. Lipase catalyzed transesterification of soybean oil for biodiesel production in tert-amyl alcohol. World J. Microbiol. Biotechnol, 2009, 25 (1), 41-46.

20、Jiang B, Quan J, Zheng Y, Zhu LM*. Enzymatic synthesis of acyclovir-galactose conjugate with liver targeting and anti-HBV activity. J. Biotechnol. 2008, 136, S380-380.

21、Zheng Y, Quan J, Zhu LM*, Jiang B, Nie HL, Optimization of selective lipase catalyzed feruloylated monoacyglycerols by response surface methodology. J. Am. Oil Chem. Soc. 2008, 85 (7), 635-639.

22、Zheng Y, Quan J, Ning X, Zhu LM*. Enhancement in Synthesis of Novel Feruloyl Lipids (Feruloyl Butyryl Glycerides) by Enzymatic Biotransformation Using Response Surface Methodology.J. Agric. Food. Chem. 2008, 56 (23), 11493-11498.

联系电话：021-67792659 EMAIL：jquan@dhu.edu.cn

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