2012-07-04 15:24 来源:未知 作者:admin 点击: 次
摘要:姓名 :邱安东 学位 :博士 研究领域 :生物医学 研究方向 : 1 、分子营养及相关人类疾病 2 、发育营养学和胚胎缺陷 3 、肾脏损伤生物标志物( Biomarker )及肾脏疾病 E-mail : andong.qiu@gmail.com 个人简介: 1993 年 6 月本科毕业于西南师范大学生物
姓 名:邱安东 学 位:博 士 研究领域:生物医学 研究方向:1、分子营养及相关人类疾病 E- mail:andong.qiu@gmail.com 个人简介: 1993年6月本科毕业于西南师范大学生物系,1996年6月于四川大学生物系获得硕士学位,同年留校任助教、讲师、副教授。2004年9月于英国伦敦国王学院获得博士学位。2004年4月开始在英国伦敦大学圣乔治医学院分子和细胞医学系和美国纽约阿尔伯特爱因斯坦医学院医学和分子药理系、癌症研究中心从事博士后研究;2007年9月-2011年12月至今在哥伦比亚大学医学系Faculty。 研究领域(具体内容): 研究人体怎样吸收、转运必需营养因子和其内平衡的代谢调控以及相关疾病的遗传基础,阐明人体细胞在病理条件下(如营养缺乏或过度积累)的遗传适应调控的分子细胞机理; 建立“发育营养学”,阐明必须营养因子在胚胎发育过程中对不同细胞来源的器官发生的遗传调控,了解与营养因子相关的胚胎缺陷发生的遗传基础,从而为预防和治疗胚胎缺陷提供新的思路;研发新一代高选择性叶酸拮抗剂抗癌药物和治疗铁过度积累疾病的新型铁螯合药物;干细胞更新和分化的营养调控机理。 专业业绩(承担项目、发表论文、教学成果): 代表性论文 1. Andong Qiu, Michaela Jansen, Antionette Sakaris, Sang Min, Shrikanta Chattopadhayay, Eugenia Tsai, Claudio Sandoval, Rongbao Zhao, Myles H Akabas, I. David Goldman. Identification of a proton-coupled intestinal folate transporter and the molecular basis for Hereditary Folate Malabsorption. Cell, 127 (5): 917-928, 2006. 2. Neal Paragas*, Andong Qiu* (Co-First Author), Qingyin Zhang, Shi-Xian Deng, Faisal Cheema, Benjamin Samstein, Vivette D’Agati, Donald W. Landry, Chyuan-Sheng Lin and Jonathan Barasch. Seeing Kidney Disease in Real Time: NGAL Reporter Mouse Detects Cellular Stressors In Vivo. Nature Medicine, 17(2): 216-22, 2011. 3. Jau Yi Li*, Neal Paragas*, Renee Ned, Andong Qiu, Kai Schmidt-Ott, Melanie Viltard, Thomas Leete, Ian Drexler, Xia Chen, Farah Mohammed, David Williams, David Williams, Chyuan-Sheng Lin, Nancy C. Andrews and Jonathan Barasch. Scara5 is a Ferritin Receptor Mediating Non-Transferrin Iron Delivery. Developmental Cell, 16(1): 35-46, 2009. 4. Guanhu Bao*, Matthew Clifton*, Trisha M. Hoette, Shi-Xian Deng, David Williams, Andong Qiu, Neal Paragas, Ritwij Kulkarni, Xiangpo Li, Belinda Lee, Avtandil Kalandadze, Kiyoshi Mori, Adam J. Ratner, Juan Carlos Pizarro, Donald W. Landry, Kenneth N. Raymond, Roland K. Strong and Jonathan Barasch. Siderocalin (Ngal, Lipocalin2) Trafficks Iron with Catecholate Metabolites. Nature Chemical Biology, 6(8): 602-609, 2010. 5. Rongbao Zhao, Sang Hee Min, Andong Qiu, Antoinette Sakaris, Gary Goldberg, Caudio Sandoval, Jeffrey J. Malatack, David S. Rosenblatt, I. David Goldman. The spectrum of mutations in the PCFT gene, coding for an intestinal folate transporter, that are the basis for Hereditary Folate Malabsorption. Blood, 110 (4): 1147-52, 2007. 6. Andong Qiu, Majid Shayeghi, Christer Hogstrand. Molecular cloning and functional characterization of a high affinity zinc importer (DrZIP1) from zebrafish, Danio rerio. Biochemical Journal, 388 (3): 745-754, 2005. 7. Andong Qiu, Christer Hogstrand. Functional expression of a low-affinity zinc uptake transporter (FrZIP2) from pufferfish (Takifugu rubripes) in MDCK cells. Biochemical Journal, 390 (3): 777-786, 2005. 8. Andong Qiu, Sang Min, Michaela Jansen, Usha Malhotra, Rongbao Zhao, Eugenia Tsai, Larry Matherly, Myles H. Akabas, I. David Goldman. Rodent intestinal folate transporters (SLC46A1): secondary structure, functional properties, response to dietary folate restriction. American Journal of Physiology-Cell Physiology, 293 (5): C1669-C1678, 2007. 9. Andong Qiu, Chris N. Glover, Christer Hogstrand. Regulation of branchial zinc uptake by 1a,25-(OH)2D3 in rainbow trout and associated changes in expression of ZIP1 and ECaC. Aquatic toxicology, 84 (2): 142-52, 2007. 10. Andong Qiu, Christer Hogstrand. Functional Characterisation and Comparative Genomic Analysis of an Epithelial Calcium Channel (ECaC) from Japanese Pufferfish, Fugu rubripes. Gene, 342 (1): 113-123, 2004. 11. Rongbao Zhao, Andong Qiu, Eugenia Tsai, Michaela Jansen, Myles H. Akabas, I. David Goldman. The Proton-Coupled Folate Transporter (PCFT): Impact on Pemetrexed Transport and on Antifolates Activities as Compared to the Reduced Folate Carrier. Molecular Pharmacology, 74(3): 854-62, 2008. 12. Ersin Selcuk Unal, Rongbao Zhao, Andong Qiu and I. David Goldman. N-linked glycosylation and its impact on the electrophoretic mobility and function of the human Proton-Coupled Folate Transporter (HsPCFT). Biochimica et Biophysica Acta – Biomembranes, 1778(6): 1407-14, 2008. |
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