科研业绩
主要研究免疫系统中的信号转导,相关研究成果相继发表在《Science》、《Nature Immunology》、《Cell Host & Microbe》等国际杂志上。
承担项目:
(1)科技部973项目(2012CB518700)(2012,1-2016,12)重要病原菌与宿主相互作用分子机制的研究(戈宝学,首席科学家)
(2)科技部973项目(2011CB505000)(2011,1-2015,12)动物流感病毒变异、跨种间传播及致病的分子机制研究 (戈宝学,学术骨干)
(3)国家基金委重点项目(31030028)(2011,1-2015,12)固有免疫中信号转导机制及应用研究 (戈宝学,项目负责人)
近五年作为通讯作者发表的文章:
1. Liu HP,Yu MC,Ge B* 2011 Supervillin associates with KIR2DL1 and regulates the cytotoxicity of natural killer cells. Cell Signal.23(2):487-96
2. Zhu QY, Liu Q, Chen JX, Miao C and Ge B* 2010 MicroRNA-101 targets MKP-1 to regulate the activation of MAP kinases in macrophages. J Immunol. 185(12):7435-42
3. Kong L, Zhang H, Qin L, Zhuang ZH, Sun L, Yu MC, Zhu J, Chen Z. Wang ZG and Ge B* 2009 An essential role for RIG-I in Toll-like receptor-mediated phagocytosis. Cell Host & Microbe 6(2):150-161. (Cited by “Faculty of 1000 Biology, Highlighted by Nature China)
4. Huang Z, Yan DP, Ge B* 2008 JNK regulates cell migration through promotion of tyrosine phosphorylation of paxillin. Cell Signal. 20(11):2002-12.
5. Yu MC, Su LL, Zou L, Liu Y, Wu N, Kong L, Zhuang ZH, Sun L, Liu HP, Hu JH, Li D, Strominger JL, Zang JW, Pei G, Ge B.* 2008 An essential function for β-arrestin 2 in the inhibitory signaling of Natural Killer cells. Nature Immunology, 9(8):898-907. (Commented in Nature Immunology, Highlighted by Nature China)
6. Kong L, Ge B*. 2008 MyD88-independent activation of a novel actin-Cdc42/Rac pathway is required for Toll-like receptor-stimulated phagocytosis. Cell Res. 18(7):745-55 (Cover Story)
7. Sun L, Yu MC, Kong L, Zhuang ZH, Hu JH, Ge B*. 2008 Molecular identification and functional characterization of a Drosophila dual-specificity phosphatase DMKP-4 which is involved in PGN-induced activation of the JNK pathway. Cell Signal. 20(7):1329-1337.
8. Hu JH, Chen T, Zhuang ZH, Kong L., Yu MC, Liu Y, Zang JW and Ge BX*. 2007 Feedback control of MKP-1 expression by p38. Cell Signal. 19(2):393-400.
9. Zhuang ZH, Zhou Y, Yu MC, Silverman N, Ge B*. 2006 Regulation of Drosophila p38 activation by specific MAP2 kinase and MAP3 kinase in response to different stimuli. Cell Signal. 18(4):441-8.
10. Zhuang ZH, Sun L, Kong L, Hu JH, Yu MC, Reinach P, Zang JW, Ge B* 2006 Drosophila TAB2 is required for the immune activation of JNK and NF-kappaB. Cell Signal. 18(7):964-70.
11. Qin LH, Long L, Shi GJ1, Wang ZT, Ge B* 2006 Andrographolide Inhibits the Production of TNF-α and Interleukin-12 in Lipopolysaccharide-stimulated Macrophages: Role of Mitogen-Activated Protein Kinases. Biol Pharm Bull. 29:220-4.
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