2012-07-04 15:28 来源:未知 作者:admin 点击: 次
摘要:姓名 :王春光 行政职务 :蛋白质研究所副所长 学位 :博士 导师情况 :博士生导师 研究领域 :蛋白质结构与功能 研究方向 : 1. 微管作为一种重要的细胞骨架,参与细胞形状和极性维持、胞内物质运输和细胞分裂等重要的生理活动。微管的动态组装和稳定性维持
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姓 名:王春光 行政职务:蛋白质研究所副所长 学 位:博士 导师情况:博士生导师 研究领域:蛋白质结构与功能 研究方向: 1. 微管作为一种重要的细胞骨架,参与细胞形状和极性维持、胞内物质运输和细胞分裂等重要的生理活动。微管的动态组装和稳定性维持受到很多因素的调节,微管状态紊乱与癌症、神经退行性疾病等密切相关。我们主要研究各种调控微管组装的蛋白质和小分子化合物的作用机理,以理解微管的调控过程及相关疾病的发生原因和药物治疗机理。 2. 动物多肽神经毒素是自然界中产毒动物经过亿万年的进化而形成的具有高活性和高选择性的神经毒素,可以作为神经生物学研究的有力工具和神经系统疾病的治疗药物。芋螺毒素因为其结构和功能的高度多样性而倍受关注,也是我们目前的主要研究对象。 E-mail:chunguangwang@tongji.edu.cn 联系电话:65984347 通讯地址:上海市四平路1239号,同济大学生命科学与技术学院(200092) 个人简历: 1991年9月-1995年7月,吉林大学生物化学与分子生物学系,获学士学位 代表性论文: 1. Weiyi Wang, Qiyang Jiang, Manuela Argentini, David Cornu, Benoît Gigant, Marcel Knossow*,Chunguang Wang*. Kif2C minimal functional domain has unusual nucleotide binding properties that are adapted to microtubule depolymerization. J. Biol. Chem. 2012, 287(18): 15143-15153. 2. Mingyu Ye, Keith K. Khoo, Shaoqiong Xu, Mi Zhou, Nonlawat Boonyalai, Matthew A. Perugini, Xiaoxia Shao, Chengwu Chi, Charles A. Galea, Chunguang Wang*, Raymond S. Norton*. Im23a, a helical conotoxin with a novel cysteine framework from Conus imperialis, defines a novel K-superfamily.J. Biol. Chem. 2012, 287(18): 14973-14983. 3. Mingyu Ye, Jing Hong, Mi Zhou, Lijun Huang, Xiaoxia Shao, Youshan Yang, Fred J. Sigworth, Chengwu Chi, Donghai Lin*, Chunguang Wang*. A novel conotoxin, qc16a, with a unique cysteine framework and folding.Peptides 2011, 32(6): 1159-1165. 4. Can Peng, Mingyu Ye, Yanfang Wang, Xiaoxia Shao, Duoduo Yuan, Jing Liu, Edward Hawrot, Chunguang Wang*, Chengwu Chi*. A new subfamily of conotoxins belonging to the A-superfamily. Peptides 2010, 31(11): 2009-2016. 5. Anthony Cormier, Marcel Knossow, Chunguang Wang and Benoit Gigant. The binding of vinca domain agents to tubulin: structural and biochemical studies. Methods in Cell Biology. 2010, 95: 369-386. 6. Ling Zhang, Xiaoxia Shao, Chengwu Chi and Chunguang Wang*. Two short D-Phe-containing cysteine-free conopeptides from Conus marmoreus.Peptides2010, 31: 177-179. 7. Yuhong Han, Feijuan Huang, Hui Jiang, Li Liu, Qi Wang, Yanfang Wang, Xiaoxia Shao, Chengwu Chi, Weihong Du and Chunguang Wang*. Purification and structural characterization of a d-amino acid-containing conopeptide, conomarphin, from Conus marmoreus. FEBS J. 2008, 275: 1976-1987. 8. Li Liu, Xuechen Wu, Duoduo Yuan, Chengwu Chi and Chunguang Wang*. Identification of a novel S-superfamily conotoxin from vermivorous Conus caracteristicus. Toxicon 2008, 51:1331-1337. 9. Can Peng, Yuhong Han, Tanya Sanders, Geoffrey Chew, Jing Liu, Edward Hawrot, Chengwu Chi and Chunguang Wang*. alpha4/7-conotoxin Lp1.1 is a novel antagonist of neuronal nicotinic acetylcholine receptors. Peptides 2008, 29(10): 1700-1707. 10. Can Peng, Li Liu, Xiaoxia Shao, Chengwu Chi and Chunguang Wang*. Identification of a novel class of conotoxins defined as V-conotoxins with a unique cysteine pattern and signal peptide sequence. Peptides 2008, 29: 985-991. 11. Chuanguang Wang, Anthony Cormier, Benoit Gigant, Marcel Knossow. Insight into the GTPase activity of tubulin from complexes with stathmin-like domains.Biochemistry, 2007, 46: 10595-10602. 12. Duoduo Yuan, Yuhong Han, Chunguang Wang*, Chengwu Chi. From the identification of gene structure of alpha conotoxins to the cloning of novel toxins. Toxicon 2007, 49: 1135–1149. 13. Can Peng, Xuechen Wu, Yuhong Han, Duoduo Yuan, Chengwu Chi and Chunguang Wang*. Identification of six novel T-1 conotoxins from Conus pulicarius by molecular cloning. Peptides 2007, 28: 2116-2124. 14. Benoît Gigant, Chunguang Wang, Raimond B. G. Ravelli, Fanny Roussi, Michel O. Steinmetz, Patrick A. Curmi, André Sobel, Marcel Knossow. Structural basis for the regulation of tubulin by vinblastine. Nature2005, 435(7041): 519-522. 15. Chunguang Wang, Zheng Cai, Wuyuan Lu, Jihui Wu, Yingqi Xu, Yunyu Shi, Chengwu Chi. A novel short-chain peptide BmKX from the chinese scorpion Buthus martensi karsch, sequencing, gene cloning and structure determination.Toxicon 2005, 45(3): 309-319. 16. Chunguang Wang, Nicolas Gilles, Alain Hamon, Frédéric Le Gall, Maria Stankiewicz, Marcel Pelhate, Yumei Xiong, Dacheng Wang, Chengwu Chi. Exploration of the functional site of a scorpion alpha-like toxin by site-directed mutagenesis. Biochemistry 2003, 42(16): 4699-4708. 17. Chunguang Wang, Maria Stankiewicz, Minhua Ling, Marcel Pelhate, Dacheng Wang, Chengwu Chi.Purification of two depressant insect neurotoxins and their gene cloning from the scorpion Buthus martensi Karsch.Journal of Peptide Research 2003,61(1):7-16. 18. Chunguang Wang, Xiaolin He, Feng Shao, Wei Liu, Minhua Ling, Dacheng Wang, Chengwu Chi. Molecular characterization of an anti-epilepsy peptide from the scorpion Buthus martensi Karsch. European Journal of Biochemistry 2001, 268(8): 2480-2485. |
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