个人简介:
1998年毕业于南京大学,主修生物物理和国际金融。2003年毕业于中国科学院生物物理研究所,获得生物信息博士学位。2000-2004在华大基因研究中心(现为中科院北京基因组研究所)任生物信息部门负责人,完成了中国第一个完整微生物全基因组测序的生物信息工作, 同时参与了人类基因组计划中国卷和水稻基因组的绘制。2004-2007年,在美国哈佛大学和Dana-Farber癌症研究所从事博士后研究。
目前担任Baylor医学院 Dan L. Duncan癌症研究所和分子细胞系的助理教授,以及NIH表观遗传组生物信息中心研究员,为总投资为1.9亿美元的NIH 表观遗传组路线图计划进行进度协调和数据分析。李蔚教授总共发表SCI论文40余篇(包括Nature, Science, Cell, Nature Genetics, PNAS, Genome Research, Bioinformatics等),并担任数家期刊的审稿人(包括Nature Method).
代表文章(Selected Publications):
1. Wang Q*, Li W*, Zhang Y, Yuan X, ..., Kantoff PW, Liu XS, Brown M: Reprogrammed Androgen Receptor Function in Androgen-Independent Prostate Cancer. Cell (2009) (* joint first authors), accepted.
2. Zhang Y, Liu T, Meyer CA, Eeckhoute J, Johnson DS, Bernstein BE, Nussbaum C, Myers RM, Brown M, Li W#, Liu XS#: Model-based Analysis of ChIP-Seq (MACS). Genome Biol. 9 (2008) R137 (# joint corresponding authors)
3. Johnson DS*, Li W*, Gordon DB, Bhattacharjee A, Curry B, Ghosh J, Brizuela L, Carroll JS, Brown M, Flicek P et al: Systematic evaluation of variability in ChIP-chip experiments using predefined DNA targets. Genome Res 18 (2008) 393-403. (* joint first authors)
4. Li W, Carroll JS, Brown M and Liu XS: xMAN: extreme MApping of OligoNucleotides. BIOCOMP′07, BMC Genomics 9(Suppl 1):S20 (2008)
5. Johnson WE*, Li W*, Meyer CA*, Gottardo R, Carroll JS, Brown M and Liu XS: Model-based analysis of tiling-arrays for ChIP-chip. Proc. Natl. Acad. Sci. U S A 103 (2006) 12457-12462. (* joint first authors)
6. Ji X*, Li W*, Song J, Wei L and Liu XS: CEAS: cis-regulatory element annotation system. Nucleic Acids Res. 34 (2006) W551-554. (* joint first authors)
7. Li W, Meyer CA and Liu XS: A hidden Markov model for analyzing ChIP-chip experiments on genome tiling arrays and its application to p53 binding sequences. Bioinformatics 21 Suppl 1 (ISMB2005) i274-i282.
8. Li W, Shi J, Wang X, Han Y, Tong W, Ma L, Liu B and Cai B: Complete nucleotide sequence and organization of the naphthalene catabolic plasmid pND6-1 from Pseudomonas sp. strain ND6. Gene 336 (2004) 231-240.
9. Bao Q*, Tian Y*, Li W*, Xu Z, Xuan Z, Hu S, Dong W, Yang J, Chen Y, Xue Y, Xu Y, Lai X, Huang L, Dong X, Ma Y, Ling L, Tan H, Chen R, Wang J, Yu J and Yang H: A Complete Sequence of the T. tengcongensis Genome. Genome Res. 12 (2002) 689-700. (* joint first authors)
10. International Human Genome Sequencing Consortium: Initial sequencing and analysis of the human genome. Nature 409 (2001) 860-921. (list author)
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