上海同济大学 医学院 范国平（教授）导师简介

导师姓名

范国平

性别

男

职    称

教授

硕士生导师

科学学位

专业名称

人体解剖学与组织胚胎学

博士生导师

科学学位

专业名称

生物医学工程 

所在院系

医学院

联系办法

通讯地址:  上海市四平路1239号同济大学医学院

 邮编: 200092

 手机: 15901901050

Email: guopingfan@gmail.com

研究方向/

主要特长

主要任职

学习经历:

1994-2001     美国麻省理工学院Whitehead Institute博士后

1990-1995     美国凯斯西储大学神经科学系，获博士学位

1986-1990     中科院上海细胞所研究生

1982-1986     南京大学生物化学系，获学士学位

工作经历:

2009-          同济大学医学院干细胞中心        讲座教授

2001-          美国加州大学洛杉矶分校医学院人类遗传学系 终身教授

科研业绩

发表论文 (2000- present的部分代表性文章):

1.    Feng, J., Zhou, Y., Campbell, SL., Le, T., Li, E., Sweatt, JD., Silva, AJ., and Fan, G. (2010). Dnmt1 and Dnmt3a maintain DNA methylation and regulate synaptic function in adult forebrain neurons. Nature Neuroscience V13, 423-430.  PMID: 20228804 (highlighted in the News and Views in the same issue of Nature Neuroscience).

2.    Liu B, Tahk S, Yee K., Fan G, Shuai K.  2010. The Ligase PIAS1 Restricts Natural Regulatory T-cell Differentiation by Epigenetic Repression.  Science V.330:521-5.

3.    Liao JL, Yu J, Huang K, Hu J, Diemer T, Ma Z, Dvash T, Yang XJ, Travis GH, Williams DS, Bok D, Fan G. 2010. Molecular Signature of Primary Retinal Pigment Epithelium and Stem-Cell derived RPE cells. Hum Mol Genet. 19(21):4229-38.

4.    Hutnick, LK., Huang,X., Loo, T-C.,  Ma, Z., and Fan G. (2010) Repression of retrotransposal elements in mouse embryonic stem cells is primarily mediated by DNA methylatoin-independent mechanism.  Journal of Biological Chemistry 285(27):21082-91 (Online version published on April 19, 2010) PMID: 20404320

5.     Dvash, T., Lavon, N., and Fan, G. (2010).  Variations of X chromosome inactivation in early passages of human embryonic stem cells.  PLoS One  5(6):e11330.

6.    Zhipeng Fan, Takayoshi Yamaza, Janice S Lee, Jianhua Yu, Songlin Wang, Fan, G., Songtao Shi, Cun-Yu Wang. 2009.  BCOR regulates mesenchymal stem cell function by epigenetic mechanisms: a case study of a rare human genetic disorder OFCD.  Nature Cell Biology 2009 Aug;11(8):1002-9. Epub 2009 Jul 5.PMID: 19578371

7.    Hutnick, L., Golshi, P., Namihira, M., Xue, Z., Matynia, A., Yang, W., Silva, A. Schweizer, F., Fan, G. (2009).  DNA hypomethylation restricted to the murine forebrain induces cortical degeneration and impairs postnatal neuronal maturation.  Human Molecular Genetics 18(15):2875-28885. 

8.    Fouse, S. Shen, Y, Pellegrini, M., Cole, S., Meissner, A., Van Neste, L., and Jaenisch, R., Fan, G. (2008).   Promoter CpG methylation contributes to ES cell-specific gene expression in parallel with the Oct4/Nanog, PcG complex, and histone H3 K4/K27 trimethylation.  Cell Stem Cell 2: 160-169. PMID: 18371437

9.     Shen, Y., Matsuno, Y.,  Fouse, SD., Rao, N., Root, S., Xu, R-H, Pellegrini, M., Riggs, A.D. and Fan, G. (2008)  X-inactivation in female human embryonic stem cells is in a non-random pattern and prone to epigenetic alternations.  PNAS 105(12):4709-14. Epub 2008 Mar 13. [PMCID: PMC2290804].

10.  Wu H, Kim KJ, Mehta K, Paxia S, Sundstrom A, Anantharaman T, Kuraishy AI, Doan T, Ghosh J, Pyle AD, Clark A, Lowry W, Fan G, Baxter T, Mishra B, Sun Y, Teitell MA. (2008) Copy Number Variant Analysis of Human Embryonic Stem Cells.  Stem Cells. 26(6):1484-9. PMID: 18369100

11.  Feng J., Fouse, S., and Fan, G.  (2007).  Epigenetic regulation of neural gene expression and neuronal function.  Pediatric Research. (Review). May;61(5 Pt 2):58R-63R 2007

12.  Golshani, P., Hutnick, L., Schweizer, F., Fan, G. (2007). Conditional Dnmt1 deletion in dorsal forebrain disrupts development of somatosensory barrel cortex and thalamocortical long-term potentiation. Thalamus and Related System  3(3):227-233.29.

13.  Shen, Y., Chow, J., Wang, Z., Fan, G. (2006).  Abnormal CpG island methylation occurs during in vitro differentiation of human embryonic stem cells.  Human Molecular Genetics.  15: 2623-2635. PMID: 16870691  

14.  Fan, G., Martinowich, K., Chin, M., He, F., Fouse, S., Hutnick, D., Hattori, D., Ge, W., Shen, Y., Wu, H., ten Hoeve, T., Shuai,  K.,  and Sun, Y. (2005).  DNA methylation controls the timing of astrogliogenesis through regulation of JAK-STAT signaling.   Development  132: 3345-3356. PMID: 16014513

15.  Martinowich, K., Hatorri, D., Wu, H., Fouse, S., He, F., Hu, Y., Fan, G*., Sun, Y*. (*Corresponding authors) (2003). DNA methylation-related chromatin remodeling in activity-dependent BDNF gene regulation.  Science 302, 890-893. PMID: 14593184

16.  Sun, Y., Nadal-Vicens, M., Misono, S., Lin, M.Z., Hua, X., Fan, G., Greenberg ME. (2001) Neurogenin promotes neurogenesis and inhibits glial differentiation by independent mechanisms.  Cell. 104, 365–376. PMID: 11239394

17.  Rio, M., Fan, G., Fekete, C., Kelly, J., Bates, B., Lechan, RM., Jaenisch, J. (2001)   Conditional deletion of brain-drived neurotrophic factor in the postnatal brain causes hyperactivity and obesity.  Molecular Endocrinology. 15, 1748-1757.

18.  Fan, G., Beard, C., Chen, R., Csankovszki, G., Sun, Y., Siniaia, M., Bates, B., Lee, P., Trumpp, A., Poon, C., Wilson, C., and Jaenisch, R. (2001) DNA hypomethylation perturbs the function and survival of CNS neurons in postnatal animals.   J. Neurosci. 21, 788-797. PMID: 11157065

19.  Fan, G., Copray, S., Wong, E., Yan, Q., Jones, K., Walro, J., Jaenisch, R., and Kucera, J.  (2000) Formation of the cranial proprioceptive system requires multiple neurotrophins.  Developmental Dynamics.  218, 359-370.      

20.  Fan, G., Egles, C., Sun, Y., Minichiello, L., Renger, J., Klein, R., Liu, G., and Jaenisch, R.  (2000)  Knocking the NT4 gene into the BDNF locus rescues BDNF deficient mice and reveals distinct NT4 and BDNF activities. Nature Neurosci. 3, 350-357.