上海同济大学 医学院 林欣（讲座教授）导师简介

1995年毕业于德克萨斯大学获生化与分子生物学专业博士学位，1995-2000年在加州大学旧金山分校病毒与免疫研究所进行博士后研究，2000-2004年在纽约州立大学Buffalo分校任助理教授，2004—2010 年在美国德克萨斯大学MD安德森癌症研究中心任终身副教授，2010—至今在美国德克萨斯大学MD安德森癌症研究中心任终身教授，2009-至今在同济大学任讲座教授。

林欣教授主要研究转录因子NF-κB 活化过程的相关信号通路，探讨其在淋巴细胞活化、炎症反应、细胞存活以及肿瘤发生中的作用及其机理。在国际上首先发现了CARMA1 作为T 细胞受体诱导NF-κB 家族活化中的关键分子，并揭示了淋巴细胞信号分子传递过程中相关的几个关键步骤，系统地阐述了T 细胞受体如何诱导NF-κB 家族活化的信号通路，同时深入全面地研究了相关的信号级联反应。相关研究成果相继发表在《Nature Immunology》、《Immunity》、《EMBO Journal》等国际一流杂志上。这些研究引起了众多免疫学者的关注并成为本领域的研究热点之一，受到国际免疫学界的认可并被众多论文广泛引用。这一研究成果已被引入新版的免疫学权威教科书《Immunobiology》。

1.        Hsu, MY., Zhang, Y.; You, Y.; Wang, D.; Li, H.; Duramad, O, Qin, X; Dong, C; Lin, X. (2007) CARD9 is required for innate immune responses against intracellular pathogens. Nature Immunology, 8(2): 198-205.

2.        Bi L, Gorjestani S, Wu W, Hsu YM, Zhu J, Ariizumi K, Lin X (2010) CARD9 mediates Dectin-2-induced IKK ubiquitination leading to activation of NF-kappaB in response to the stimulation by the hyphal form of Candida albicans. J. Biol. Chem. Aug 20; 285(34): 25969-77

3.        Wu W, Hsu YM, Bi L, Songyang Z, Lin X. (2009) CARD9 facilitates microbe-elicited production of reactive oxygen species by regulating the LyGDI-Rac1 complex. Nature Immunology. Nov; 10(11):1208-14

4.        Sun, J. and Lin X. (2008) b-arrestin 2 is required for lysophosphatidic acid-induced NF-kB activation. Proc. Natl. Acad. Sci. USA (Track II), Nov 4;105(44):17085-90.

5.        Jiang T, Grabiner B, Zhu Y, Jiang C, Li H, You Y, Lang J, Hung M-C, Lin X (2011) CARMA3 is crucial for EGF-induced activation of NF-kB and tumor progression. Cancer Research. In press

6.        Nurieva RI, Zheng S, Jin W, Chung Y, Zhang Y, Martinez GJ, Reynolds JM, Wang SL, Lin X, Sun SC, Lozano G, Dong C. (2010) The E3 ubiquitin ligase GRAIL regulates T cell tolerance and regulatory T cell function by mediating T cell receptor-CD3 degradation. Immunity. May 28;32(5):670-80.

7.        Yang WL, Wang J, Chan CH, Lee SW, Campos AD, Lamothe B, Hur L, Grabiner BC, Lin X, Darnay BG, Lin HK (2009) The E3 ligase TRAF6 regulates Akt ubiquitination and activation. Science. Aug. 28; 325 (5944): 1134-8

8.        Blonska, M, and Lin X (2009) CARMA1-mediated NF-kB and JNK activation in lymphocytes. Immunological Reviews (Invited review), Mar; 228(1): 199-211

9.        Li, H and Lin X. (2008) Positive and Negative Signaling Components involved in TNFa-induced NF-kB Activation. Cytokine, (Invited review) Jan;41(1):1-8.

10.    Tanner, MJ; Hanel, W.; Gaffen, SL; Lin X. (2007) CARMA1 Coiled-coil domain is involved in the oligomerization and subcellular localization of CARMA1, and is required for T cell receptor-induced NF-kB activation. J. Biol. Chem. 282 (23): 17141-7

11.    Grabiner, B.; Lin, P.; Blonska, M.; You, Y.; Wang, D.; Sun, J.; Darnay, BG; Dong, C.; Lin X. (2007) CARMA3 deficiency abrogates G protein-coupled receptor-induced NF-kB activation. Genes & Development. 21(8): 984-96

12.    Shambharkar, P.B.; Blonska, M; Pappu, B.P.; Li, H.; You, Y.; Darnay, B.; Lin X. (2007) Phosphorylation and ubiquitination of IKK complex by two distinct signaling pathways. EMBO J. 26(7): 1794-805.

13.    Blonska, M.; Pappu, B.; Li, H.; Matsumoto R.; Su, B.; Wang, D.; Lin X. (2007) The CARMA1-Bcl10 complex selectively regulates JNK2 in the T cell receptor signaling pathway. Immunity, 26(1): 55-66.

14.    Wang, D.; You, Y.; Lin, P.; Xue, L.; Morris, S.; Zeng, H.; Wen, R., Lin X. (2007) Bcl10 is required for G protein-coupled receptor-induced NF-kB activation. Proc. Natl. Acad. Sci. USA, 104(1): 145-50.